Lexicon to Report 3Q Financial Results

Conference Call and Webcast to Follow

The Woodlands, TX -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) will release its third quarter 2007 financial results on Tuesday, October 30, 2007 after the financial markets close. Lexicon management will hold a conference call to discuss the company's results and provide financial guidance for the fourth quarter of 2007 at 5:00 p.m. Eastern Time on October 30, 2007.

The dial-in number for the conference call is 877-874-1569 (within the United States) or 719-325-4796 (international). The pass code for all callers is 1913448. Investors can access a live webcast of the call at the company's Web site. An archived version of the webcast will be available on the Web site through November 2, 2007.

About Lexicon
Lexicon is a biopharmaceutical company focused on the discovery and development of breakthrough treatments for human disease. Lexicon currently has clinical programs underway for such areas of major unmet medical need as irritable bowel syndrome and cognitive disorders. The company has used its proprietary gene knockout technology to discover more than 100 promising drug targets and create an extensive pipeline of clinical and preclinical programs in the therapeutic areas of diabetes and obesity, cardiovascular disease, psychiatric and neurological disorders, cancer, immune system disorders and ophthalmic disease. To advance the development and commercialization of its programs, Lexicon is working both independently and through collaborators including Bristol-Myers Squibb Company, Genentech, Inc., N.V. Organon and Takeda Pharmaceutical Company Limited. For additional information about Lexicon and its programs, please visit Lexicon's Web site.