Lexicon Presents Clinical Results at Rheumatology Meeting

THE WOODLANDS, Texas -- Lexicon Pharmaceuticals, Inc. (Nasdaq:LXRX), a biopharmaceutical company focused on discovering and developing breakthrough treatments for human disease, will be presenting results at the American College of Rheumatology annual meeting from its Phase 1 clinical trials of LX2931.

Lexicon will also be presenting results from its preclinical research demonstrating activity of LX2931 in models of rheumatoid arthritis and inflammation. LX2931 is an orally-delivered, small molecule drug candidate that has successfully completed Phase 1 testing in normal volunteers. Lexicon is planning to progress LX2931 into a drug-drug interaction study in rheumatoid arthritis patients who are also taking methotrexate, a standard therapy.

In the recently completed Phase 1b multiple ascending-dose trial, LX2931 was well tolerated at all doses, including the maximum dose of 150 mg per day, over the seven day dosing period. Results from this trial demonstrated a dose-dependent reduction in circulating lymphocytes, confirming the mechanism of action of LX2931 in regulating lymphocyte trafficking. The lymphocyte reductions observed in the multiple dose study are similar to those associated with a beneficial response obtained in animal models of arthritis after treatment with LX2931.

"We continue to be encouraged that multiple doses of LX2931 were well tolerated and produced a dose-dependent reduction in lymphocytes consistent with levels at which our results in animal models predict disease modifying activity," said Philip M. Brown, M.D., J.D., senior vice president of clinical development at Lexicon.